ツゲ ヒデアキ
TSUGE HIDEAKI
津下 英明 所属 京都産業大学 生命科学部 先端生命科学科 職種 教授 |
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言語種別 | 英語 |
発行・発表の年月 | 2009/01 |
形態種別 | 研究論文 |
査読 | 査読あり |
標題 | Structural analysis of human glutamine:fructose-6-phosphate amidotransferase, a key regulator in type 2 diabetes |
執筆形態 | その他 |
掲載誌名 | FEBS LETTERS |
出版社・発行元 | ELSEVIER SCIENCE BV |
巻・号・頁 | 583(1),pp.163-167 |
著者・共著者 | Yuichiro Nakaishi,Masahiko Bando,Hiroshi Shimizu,Kenji Watanabe,Fumitaka Goto,Hideaki Tsuge,Kazumi Kondo,Makoto Komatsu |
概要 | Glutamine: fructose-6-phosphate amidotransferase (GFAT) is a rate-limiting enzyme in the hexoamine biosynthetic pathway and plays an important role in type 2 diabetes. We now report the first structures of the isomerase domain of the human GFAT in the presence of cyclic glucose-6-phosphate and linear glucosamine-6-phosphate. The C-terminal tail including the active site displays a rigid conformation, similar to the corresponding Escherichia coli enzyme. The diversity of the CF helix near the active site suggests the helix is a major target for drug design. Our study provides insights into the development of therapeutic drugs for type 2 diabetes. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved. |
DOI | 10.1016/j.febslet.2008.11.041 |
ISSN | 0014-5793 |