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イタノ ナオキ
ITANO NAOKI
板野 直樹 所属 京都産業大学 生命科学部 先端生命科学科 職種 教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2008/01 |
| 形態種別 | 研究論文 |
| 査読 | 査読あり |
| 標題 | Significance of tumor-associated stroma in promotion of intratumoral lymphangiogenesis - Pivotal role of a hyaluronan-rich tumor microenvironment |
| 執筆形態 | その他 |
| 掲載誌名 | AMERICAN JOURNAL OF PATHOLOGY |
| 出版社・発行元 | AMER SOC INVESTIGATIVE PATHOLOGY, INC |
| 巻・号・頁 | 172(1),pp.179-193 |
| 著者・共著者 | Hiroshi Koyama,Nobutaka Kobayashi,Michihiko Harada,Michiko Takeoka,Yoshiko Kawai,Kenji Sano,Minoru Fujimori,Jun Amano,Toshio Ohhashi,Reiji Kannagi,Koji Kimata,Shun'ichiro Taniguchi,Naoki Itano |
| 概要 | Stromal cells, together with extracellular matrix components, provide a tumor microenvironment that is pivotal for cancer cell growth and progression. In our previous study using a conditional transgenic mouse model of breast cancer, the overproduction of hyaluronan, a major extracellular constituent, accelerated tumor angiogenesis through stromal cell recruitment. This finding led us to investigate the role of hyaluronan in the lymphatic vessel system. Here, we have found that microenvironmental hyaluronan promoted tumor lymphangiogenesis concurrently with the formation of stromal structures. Additionally, lymphatic vessels frequently penetrated and accumulated into stromal compartments, and up-regulation of vascular endothelial growth factor-C and -D was detected at tumor-stromal interfaces. To assess the contribution of stromal cells to lymphangiogenesis in vivo, we established tumor-associated fibroblasts from hyaluronan-overproducing mammary tumors and implanted them together with carcinoma cells from control tumors or MCF-7 human breast carcinoma cells in nude mice. Carcinoma cells grew rapidly in association with marked stromal reactions and lymphangiogenesis. Without the stromal cells, however, the tumors developed slowly with less stroma and lymphatic vessels. These findings underline the significance of tumor-associated stroma in the promotion of intratumoral lymphangiogenesis and suggest a pivotal role for the hyaluronan-rich tumor microenvironment. |
| DOI | 10.2353/ajpath.2008.070360 |
| ISSN | 0002-9440 |