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ハマノ ツヨシ
HAMANO TSUYOSHI
濱野 強 所属 京都産業大学 現代社会学部 健康スポーツ社会学科 職種 教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2016/03 |
| 形態種別 | 研究論文 |
| 査読 | 査読あり |
| 標題 | Effect of salt intake on blood pressure in patients receiving antihypertensive therapy: Shimane CoHRE Study |
| 執筆形態 | その他 |
| 掲載誌名 | EUROPEAN JOURNAL OF INTERNAL MEDICINE |
| 出版社・発行元 | ELSEVIER SCIENCE BV |
| 巻・号・頁 | 28,pp.70-73 |
| 著者・共著者 | Tomoko Ito,Miwako Takeda,Tsuyoshi Hamano,Tsunetaka Kijima,Masayuki Yamasaki,Minoru Isomura,Shozo Yano,Kuninori Shiwaku,Toru Nabika |
| 概要 | Background: Salt intake is recognized as an important risk factor for hypertension in the general population. On the other hand, the availability of various classes of antihypertensive drugs means that it is generally not considered crucial to control the salt intake of hypertensive patients. In this study, we evaluated whether blood pressure (BP) was correlated with 24-hour salt intake in patients receiving antihypertensive therapy.
Methods: A total of 1496 consecutive participants undergoing health screening examinations were recruited. Subjects were divided into two groups according to their antihypertensive medications checked on prescriptions: 1005 subjects without antihypertensive therapy (untreated subjects) and 491 subjects with antihypertensive therapy (treated subjects). The 24-hour urinary sodium excretion (24 h-uNa), a surrogate marker for daily salt intake, was estimated with the formula proposed by Tanaka et al. in 2002. Results: Univariate analysis indicated that 24 h-uNa was positively correlated with the systolic BP of both untreated and treated subjects. This was confirmed by multiple linear regression analysis after adjustment for confounding factors (untreated subjects: partial regression coefficient beta = 1.45 +/- 0.26, p < 0.001; treated subjects: beta = 0.75 +/- 0.27, p = 0.01). Salt intake was also correlated with the pulse pressure in both treated subjects (beta = 0.55 +/- 0.24, p = 0.02) and untreated subjects (beta = 0.93 +/- 0.19, p < 0.001). Conclusion: These results suggest the importance of reducing salt intake in hypertensive patients on pharmacotherapy, as well as in the general population. Further studies of hypertensive patients employing 24-h urine collection are warranted to confirm the present findings. (C) 2015 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved. |
| DOI | 10.1016/j.ejim.2015.10.013 |
| ISSN | 0953-6205/1879-0828 |