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エンドウ トシヤ
ENDO TOSHIYA
遠藤 斗志也 所属 京都産業大学 生命科学部 先端生命科学科 職種 客員教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2022/11 |
| 形態種別 | 研究論文 |
| 標題 | Dissociation of ERMES clusters plays a key role in attenuating the endoplasmic reticulum stress. |
| 執筆形態 | その他 |
| 掲載誌名 | iScience |
| 掲載区分 | 国外 |
| 巻・号・頁 | 25(11),pp.105362-105362 |
| 著者・共著者 | Yuriko Kakimoto-Takeda,Rieko Kojima,Hiroya Shiino,Manatsu Shinmyo,Kazuo Kurokawa,Akihiko Nakano,Toshiya Endo,Yasushi Tamura |
| 概要 | In yeast, ERMES, which mediates phospholipid transport between the ER and mitochondria, forms a limited number of oligomeric clusters at ER-mitochondria contact sites in a cell. Although the number of the ERMES clusters appears to be regulated to maintain proper inter-organelle phospholipid trafficking, its underlying mechanism and physiological relevance remain poorly understood. Here, we show that mitochondrial dynamics control the number of ERMES clusters. Moreover, we find that ER stress causes dissociation of the ERMES clusters independently of Ire1 and Hac1, canonical ER-stress response pathway components, leading to a delay in the phospholipid transport from the ER to mitochondria. Our biochemical and genetic analyses strongly suggest that the impaired phospholipid transport contributes to phospholipid accumulation in the ER, expanding the ER for ER stress attenuation. We thus propose that the ERMES dissociation constitutes an overlooked pathway of the ER stress response that operates in addition to the canonical Ire1/Hac1-dependent pathway. |
| DOI | 10.1016/j.isci.2022.105362 |
| PMID | 36339260 |