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ハマノ ツヨシ
HAMANO TSUYOSHI
濱野 強 所属 京都産業大学 現代社会学部 健康スポーツ社会学科 職種 教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2016/09 |
| 形態種別 | 研究論文 |
| 査読 | 査読あり |
| 標題 | Familial Transmission of Hospital-Treated Varicose Veins in Adoptees: A Swedish Family Study |
| 執筆形態 | その他 |
| 掲載誌名 | JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS |
| 出版社・発行元 | ELSEVIER SCIENCE INC |
| 巻・号・頁 | 223(3),pp.452-460 |
| 著者・共著者 | Kunie Kohno,Hiroyuki Niihara,Xinjun Li,Tsuyoshi Hamano,Toru Nabika,Kuninori Shiwaku,Minoru Isomura,Eishin Morita,Kristina Sundquist,Bengt Zoller |
| 概要 | BACKGROUND: Varicose veins (VVs) cluster in families, but the familial risk of VVs has not been determined among adoptees. The aim was to estimate whether the familial transmission of VVs is related to disease in biological and/or adoptive parents.
STUDY DESIGN: The Swedish Multi-Generation Register and the Swedish Patient Register were used to follow all Swedish-born adoptees (born 1932 through 2004) that could be linked to both their biological and their adoptive parents (n = 80,214; 50% females). The risk of VVs was estimated in adoptees with at least 1 biological parent with VVs, but no adoptive parent with VVs (n = 187) compared with adoptees without a biological or adoptive parent with VVs (n = 1,758). The risk of VVs was also determined in adoptees with at least 1 adoptive parent, but no biological parent with VVs (n = 87), and in adoptees with both biological and adoptive parents affected (n = 21). RESULTS: Adoptees from an affected biological parent, but no adoptive parent, were more likely to have VVs than adoptees from an unaffected biological or adoptive parent (standard incidence ratio [SIR] = 2.21; 95% CI, 1.91e2.55). The familial SIR for adoptees with both an affected biological parent and an adoptive parent was 4.58 (95% CI, 2.83-7.01). Adoptees with an affected adoptive parent but no biological parent were not at increased risk of VVs (SIR = 1.15; 95% CI, 0.92-1.42). CONCLUSIONS: These novel findings suggest that genetic factors make a strong contribution to the familial transmission of VVs from parents to offspring, although familial environmental factors might contribute. (C) 2016 by the American College of Surgeons. Published by Elsevier Inc. All rights reserved. |
| DOI | 10.1016/j.jamcollsurg.2016.06.007 |
| ISSN | 1072-7515/1879-1190 |