|
イタノ ナオキ
ITANO NAOKI
板野 直樹 所属 京都産業大学 生命科学部 先端生命科学科 職種 教授 |
|
| 言語種別 | 英語 |
| 発行・発表の年月 | 2008/08 |
| 形態種別 | その他 |
| 査読 | 査読あり |
| 標題 | Altered hyaluronan biosynthesis in cancer progression |
| 執筆形態 | その他 |
| 掲載誌名 | SEMINARS IN CANCER BIOLOGY |
| 出版社・発行元 | ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD |
| 巻・号・頁 | 18(4),pp.268-274 |
| 著者・共著者 | Naoki Itano,Koji Kimata |
| 概要 | Microenvironmental stimuli can influence the malignant phenotype of cancer cells. Notably, the altered biosynthesis of hyaluronan, a constituent of the extracellular microenvironment, has been implicated in the progress and metastasis of carcinomas. The discovery of hyaluronan synthase (HAS) genes, which encode the key enzymes in hyaluronan biosynthesis, has enabled great strides in understanding the mechanism, underlying altered hyaluronan production in cancer and the involvement of this polysaccharide in tumor progression. Recent studies using HAS transgenic mice have provided evidence that overproduction of hyaluronan in mammary tumors accelerates tumor growth through the recruitment of stromal cells and vasculature, revealing further insight into how increased hyaluronan influences the malignant behaviors of cancer cells. (c) 2008 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.semcancer.2008.03.006 |
| ISSN | 1044-579X |