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イタノ ナオキ
ITANO NAOKI
板野 直樹 所属 京都産業大学 生命科学部 先端生命科学科 職種 教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2008/08 |
| 形態種別 | その他 |
| 査読 | 査読あり |
| 標題 | Simple primary structure, complex turnover regulation and multiple roles of hyaluronan |
| 執筆形態 | その他 |
| 掲載誌名 | JOURNAL OF BIOCHEMISTRY |
| 出版社・発行元 | OXFORD UNIV PRESS |
| 巻・号・頁 | 144(2),pp.131-137 |
| 著者・共著者 | Naoki Itano |
| 概要 | Hyaluronan is a major macromolecular polysaccharide component of the extra-cellular matrix that confers structural frameworks for cells. Despite its relatively simple chemical composition, hyaluronan mediates many other important functional aspects including signalling activity during embryonic morphogenesis, cellular regeneration and wound healing. Abnormalities in hyaluronan metabolism have been implicated in many diseases, such as inflammatory disorders, cardiovascular diseases and cancer. To date, it has become increasingly clear that hyaluronan production in vertebrates is tightly regulated by three hyaluronan synthases and that hyaluronan catabolism is regulated by an enzymatic degradation reaction involving several hyaluronidases. Together, these discoveries have provided key insights into the physiological roles of hyaluronan and a deeper understanding of the mechanisms underlying altered hyaluronan turnover in diseases. The central aim of this review article is therefore to highlight the multiple roles of hyaluronan in physiological and pathological states via its complex turnover regulation. |
| DOI | 10.1093/jb/mvn046 |
| ISSN | 0021-924X |