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イタノ ナオキ
ITANO NAOKI
板野 直樹 所属 京都産業大学 生命科学部 先端生命科学科 職種 教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2008/09 |
| 形態種別 | その他 |
| 査読 | 査読あり |
| 標題 | Impact of the hyaluronan-rich tumor microenvironment on cancer initiation and progression |
| 執筆形態 | その他 |
| 掲載誌名 | CANCER SCIENCE |
| 出版社・発行元 | WILEY-BLACKWELL |
| 巻・号・頁 | 99(9),pp.1720-1725 |
| 著者・共著者 | Naoki Itano,Lisheng Zhuo,Koji Kimata |
| 概要 | Hyaluronan acts as a microenvironmental stimulus that can influence the malignant phenotype of cancer cells. During cancer progression, hyaluronan assembles an extracellular matrix that is favorable for both the motility and proliferation of cancer cells and the recruitment of inflammatory and bone marrow-derived progenitor cells. The varied roles of this polysaccharide are regulated via multiple mechanisms involving biosynthesis, degradation, binding with other extracellular molecules, and activation of signaling pathways. Recent animal studies have provided evidence that aberrant biosynthesis of hyaluronan accelerates tumor growth through a diverse repertoire of host-tumor interactions, such as stromal cell recruitment, angiogenesis, lymphangiogenesis, and inflammation. Hyaluronan in the tumor microenvironment thus significantly impacts cancer initiation and progression via stroma-cancer cell interactions. |
| DOI | 10.1111/j.1349-7006.2008.00885.x |
| ISSN | 1347-9032 |