|
ヨコヤマ ケン
YOKOYAMA KEN
横山 謙 所属 京都産業大学 生命科学部 先端生命科学科 職種 教授 |
|
| 言語種別 | 英語 |
| 発行・発表の年月 | 2018/01/01 |
| 形態種別 | 研究論文 |
| 査読 | 査読あり |
| 標題 | General anesthetics cause mitochondrial dysfunction and reduction of intracellular ATP levels |
| 執筆形態 | その他 |
| 掲載誌名 | PLoS ONE |
| 出版社・発行元 | Public Library of Science |
| 巻・号・頁 | 13(1),pp.e0190213 |
| 著者・共著者 | Jun-ichi Kishikawa,Yuki Inoue,Makoto Fujikawa,Kenji Nishimura,Atsuko Nakanishi,Tsutomu Tanabe,Hiromi Imamura,Ken Yokoyama |
| 概要 | General anesthetics are indispensable for effective clinical care. Although, the mechanism of action of general anesthetics remains controversial, lipid bilayers and proteins have been discussed as their targets. In this study, we focused on the relationship between cellular ATP levels and general anesthetics. The ATP levels of nematodes and cultured mammalian cells were decreased by exposure to three general anesthetics: isoflurane, pentobarbital, and 1-phenoxy-2-propanol. Furthermore, these general anesthetics abolished mitochondrial membrane potential, resulting in the inhibition of mitochondrial ATP synthesis. These results suggest that the observed decrease of cellular ATP level is a common phenomenon of general anesthetics. |
| DOI | 10.1371/journal.pone.0190213 |
| ISSN | 1932-6203 |
| PMID | 29298324 |