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ツゲ ヒデアキ
TSUGE HIDEAKI
津下 英明 所属 京都産業大学 生命科学部 先端生命科学科 職種 教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2015 |
| 形態種別 | 研究論文 |
| 招待論文 | 招待あり |
| 標題 | Reaction Mechanism of Mono-ADP-Ribosyltransferase Based on Structures of the Complex of Enzyme and Substrate Protein. |
| 執筆形態 | その他 |
| 掲載誌名 | Curr Top Microbiol Immunol.-ENDOGENOUS ADP-RIBOSYLATION |
| 出版社・発行元 | SPRINGER-VERLAG BERLIN |
| 巻・号・頁 | 384(384),pp.69-87 |
| 担当区分 | 筆頭著者,責任著者 |
| 著者・共著者 | Tsuge H,Tsurumura T |
| 概要 | Mono-ADP-ribosylation is a post-translational protein modification catalyzed by bacterial toxins and exoenzymes that function as ADP-ribosyltransferases. Despite the importance of this modification, the reaction mechanism remains poorly understood due to a lack of information on the crystal structure of these enzymes in complex with a substrate protein. Recently, the structures of two such complexes became available, which shed new light on the mechanisms of mono-ADP-ribosylation. In this review, we consider the reaction mechanism based on the structures of ADP-ribosyltransferases in complex with a substrate protein. |
| DOI | 10.1007/82_2014_415 |
| ISSN | 0070-217X |
| PMID | 24990621 |
| Put Code(ORCID) | 15820427 |
| PermalinkURL | http://europepmc.org/abstract/med/24990621 |