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若林 憲一 所属 京都産業大学 生命科学部 産業生命科学科 職種 教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2021/02 |
| 形態種別 | 研究論文 |
| 査読 | 査読あり |
| 標題 | A dynein-associated photoreceptor protein prevents ciliary acclimation to blue light |
| 執筆形態 | その他 |
| 掲載誌名 | Science Advances |
| 掲載区分 | 国外 |
| 出版社・発行元 | American Association for the Advancement of Science (AAAS) |
| 巻・号・頁 | 7(9),pp.eabf3621-eabf3621 |
| 著者・共著者 | Osamu Kutomi,Ryosuke Yamamoto,Keiko Hirose,Katsutoshi Mizuno,Yuuhei Nakagiri,Hiroshi Imai,Akira Noga,Jagan Mohan Obbineni,Noemi Zimmermann,Masako Nakajima,Daisuke Shibata,Misa Shibata,Kogiku Shiba,Masaki Kita,Hideo Kigoshi,Yui Tanaka,Yuya Yamasaki,Yuma Asahina,Chihong Song,Mami Nomura,Mamoru Nomura,Ayako Nakajima,Mia Nakachi,Lixy Yamada,Shiori Nakazawa,Hitoshi Sawada,Kazuyoshi Murata,Kaoru Mitsuoka,Takashi Ishikawa,Ken-ichi Wakabayashi,Takahide Kon,Kazuo Inaba |
| 概要 | Light-responsive regulation of ciliary motility is known to be conducted through modulation of dyneins, but the mechanism is not fully understood. Here, we report a novel subunit of the two-headed f/I1 inner arm dynein, named DYBLUP, in animal spermatozoa and a unicellular green alga. This subunit contains a BLUF (sensors of blue light using FAD) domain that appears to directly modulate dynein activity in response to light. DYBLUP (dynein-associated BLUF protein) mediates the connection between the f/I1 motor domain and the tether complex that links the motor to the doublet microtubule.<italic>Chlamydomonas</italic>lacking the DYBLUP ortholog shows both positive and negative phototaxis but becomes acclimated and attracted to high-intensity blue light. These results suggest a mechanism to avoid toxic strong light via direct photoregulation of dyneins. |
| DOI | 10.1126/sciadv.abf3621 |
| ISSN | /2375-2548 |
| PMID | 33637535 |
| Put Code(ORCID) | 97421867 |
| PermalinkURL | https://syndication.highwire.org/content/doi/10.1126/sciadv.abf3621 |