|
エンドウ トシヤ
ENDO TOSHIYA
遠藤 斗志也 所属 京都産業大学 生命科学部 先端生命科学科 職種 客員教授 |
|
| 言語種別 | 英語 |
| 発行・発表の年月 | 2003/08 |
| 形態種別 | 研究論文 |
| 査読 | 査読あり |
| 標題 | Functional cooperation and separation of translocators in protein import into mitochondria, the double-membrane bounded organelles |
| 執筆形態 | その他 |
| 掲載誌名 | JOURNAL OF CELL SCIENCE |
| 出版社・発行元 | COMPANY OF BIOLOGISTS LTD |
| 巻・号・頁 | 116(16),pp.3259-3267 |
| 著者・共著者 | T Endo,H Yamamoto,M Esaki |
| 概要 | Nearly all mitochondrial proteins are synthesized in the cytosol and subsequently imported into mitochondria with the aid of translocators: the TOM complex in the outer membrane, and the TIM23 and TIM22 complexes in the inner membrane. The TOM complex and the TIM complexes cooperate to achieve efficient transport of proteins to the matrix or into the inner membrane and several components, including Tom22, Tim23, Tim50 and small Tim proteins, mediate functional coupling of the two translocator systems. The TOM complex can be disconnected from the TIM systems and their energy sources (ATP and DeltaPsi), however, using alternative mechanisms to achieve vectorial protein translocation across the outer membrane. |
| DOI | 10.1242/jcs.00667 |
| ISSN | 0021-9533 |