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ツゲ ヒデアキ
TSUGE HIDEAKI
津下 英明 所属 京都産業大学 生命科学部 先端生命科学科 職種 教授 |
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| 言語種別 | 日本語 |
| 発行・発表の年月 | 2024/05 |
| 形態種別 | 研究論文 |
| 査読 | 査読あり |
| 標題 | Structural Elucidation and Antiviral Activity of Covalent Cathepsin L Inhibitors. |
| 執筆形態 | 共著 |
| 掲載誌名 | Journal of medicinal chemistry |
| 掲載区分 | 国外 |
| 巻・号・頁 | 67(9),7048-7067頁 |
| 著者・共著者 | Falke Sven, Lieske Julia, Herrmann Alexander, Loboda Jure, Karničar Katarina, Günther Sebastian, Reinke Patrick Y A, Ewert Wiebke, Usenik Aleksandra, Lindič Nataša, Sekirnik Andreja, Dretnik Klemen, Tsuge Hideaki, Turk Vito, Chapman Henry N, Hinrichs Winfried, Ebert Gregor, Turk Dušan, Meents Alke |
| 概要 | Emerging RNA viruses, including SARS-CoV-2, continue to be a major threat. Cell entry of SARS-CoV-2 particles via the endosomal pathway involves cysteine cathepsins. Due to ubiquitous expression, cathepsin L (CatL) is considered a promising drug target in the context of different viral and lysosome-related diseases. Crystal structures of CatL in complex with 14 compounds at resolutions better than 2 Å present a solid basis for structure-guided understanding and optimization of CatL inhibitors toward protease drug development. |
| DOI | 10.1021/acs.jmedchem.3c02351 |
| ISSN | 1520-4804 |
| PMID | 38630165 |