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ナカムラ ノブヒロ
NAKAMURA NOBUHIRO
中村 暢宏 所属 京都産業大学 生命科学部 先端生命科学科 職種 教授 |
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| 言語種別 | 英語 |
| 発行・発表の年月 | 2010/03 |
| 形態種別 | 記事・総説・解説・論説等（学術雑誌） |
| 査読 | 査読あり |
| 招待論文 | 招待あり |
| 標題 | Emerging new roles of GM130, a cis-Golgi matrix protein, in higher order cell functions |
| 執筆形態 | 単著 |
| 掲載誌名 | Journal of Pharmacological Sciences |
| 掲載区分 | 国内 |
| 巻・号・頁 | 112(3),pp.255-264 |
| 担当区分 | 責任著者 |
| 著者・共著者 | Nobuhiro Nakamura |
| 概要 | GM130 is a peripheral membrane protein strongly attached to the Golgi membrane and is isolated from the detergent and salt resistant Golgi matrix. GM130 is rich in coiled-coil structures and predicted to take a rod-like shape. Together with p115, giantin, and GRASP65, GM130 facilitates vesicle fusion to the Golgi membrane as a vesicle "tethering factor". GM130 is also involved in the maintenance of the Golgi structure and plays a major role in the disassembly and reassembly of the Golgi apparatus during mitosis. Emerging evidence suggests that GM130 is involved in the control of glycosylation, cell cycle progression, and higher order cell functions such as cell polarization and directed cell migration. This creates the potential for novel Golgi-targeted drugs and treatments for various diseases including glycosylation defects, immune diseases, and cancer. © 2010 The Japanese Pharmacological Society. |
| DOI | 10.1254/jphs.09R03CR |
| ISSN | 1347-8613 |
| PMID | 20197635 |
| Put Code(ORCID) | 19809391 |