教員情報 - 横山　謙 | 京都産業大学

ヨコヤマ　ケン YOKOYAMA KEN
横山　謙

所属

京都産業大学生命科学部先端生命科学科

職種教授

著書・論文歴
2024/11	論文	Human F-ATP synthase as a drug target Pharmacological Research 209,107423-107423頁
2023/07	論文	Mechanism of ATP hydrolysis dependent rotation of bacterial ATP synthase. Nature communications 14 (1),4090-4090頁
2023/07	その他	タンパク質の構造解析手法とIn silicoスクリーニングへの応用事例
2023/01	論文	Cryo-EM analysis of V/A-ATPase intermediates reveals the transition of the ground-state structure to steady-state structures by sequential ATP binding. The Journal of biological chemistry,102884-102884頁
2022/10	その他	Structural transition of the ground-state structure to steady-state structures by sequential binding of ATP to V/A-ATPase
2022/08	論文	Structural basis of unisite catalysis of bacterial F0F1-ATPase PNAS Nexus 1 (3)
2022/07	論文	Structures of Multisubunit Membrane Complexes With the CRYO ARM 200. Microscopy (Oxford, England) 71 (5),249-261頁
2018/12/01	論文	Cryo em structure of intact rotary H+-ATPase/synthase from Thermus thermophilus Nature Communications 9 (1),89
2018/01/01	論文	General anesthetics cause mitochondrial dysfunction and reduction of intracellular ATP levels PLoS ONE 13 (1),e0190213
2016/10	論文	Rotation of artificial rotor axles in rotary molecular motors PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 113 (40),11214-11219頁
2015/09/01	論文	GraDeR: Membrane Protein Complex Preparation for Single-Particle Cryo-EM. Structure (London, England : 1993) 23 (9),1769-1775頁
2015/03	論文	The Ingenious Structure of Central Rotor Apparatus in VoV1; Key for Both Complex Disassembly and Energy Coupling between V-1 and V-o PLOS ONE 10 (3),e0119602
2014/09	論文	F-subunit reinforces torque generation in V-ATPase EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS 43 (8-9),415-422頁
2014/01	論文	Molecular Basis of ADP Inhibition of Vacuolar (V)-type ATPase/Synthase JOURNAL OF BIOLOGICAL CHEMISTRY 289 (1),403-412頁
2013/08	論文	In Vivo Fluorescent Adenosine 5'-Triphosphate (ATP) Imaging of Drosophila melanogaster and Caenorhabditis elegans by Using a Genetically Encoded Fluorescent ATP Biosensor Optimized for Low Temperatures ANALYTICAL CHEMISTRY 85 (16),7889-7896頁
2013/08	論文	Visualization of two distinct states of disassembly in the bacterial V-ATPase from Thermus thermophilus MICROSCOPY 62 (4),467-474頁
2013/05	論文	Common Evolutionary Origin for the Rotor Domain of Rotary Atpases and Flagellar Protein Export Apparatus PLOS ONE 8 (5),e64695
2013/01	論文	Mechanical Modulation of ATP-binding Affinity of V-1-ATPase JOURNAL OF BIOLOGICAL CHEMISTRY 288 (1),619-623頁
2013	その他	膜タンパク質構造研究
2012/08	論文	Single-molecule Analysis of Inhibitory Pausing States of V-1-ATPase JOURNAL OF BIOLOGICAL CHEMISTRY 287 (34),28327-28335頁
2012/07	論文	Reconstitution of Vacuolar-type Rotary H+-ATPase/Synthase from Thermus thermophilus JOURNAL OF BIOLOGICAL CHEMISTRY 287 (29),24597-24603頁
2012/01	論文	MRT letter: Expression of ATP sensor protein in Caenorhabditis elegans MICROSCOPY RESEARCH AND TECHNIQUE 75 (1),15-19頁
2011/03	論文	Resolving stepping rotation in Thermus thermophilus H+-ATPase/synthase with an essentially drag-free probe NATURE COMMUNICATIONS 2,233
2009/12	論文	Crystal structure of A(3)B(3) complex of V-ATPase from Thermus thermophilus EMBO JOURNAL 28 (23),3771-3779頁
2009/02	論文	Cryo-EM Structure of the Native GroEL-GroES Complex from Thermus thermophilus Encapsulating Substrate Inside the Cavity STRUCTURE 17 (2),287-293頁
2009/02	論文	Mechanism of Inhibition of the V-Type Molecular Motor by Tributyltin Chloride BIOPHYSICAL JOURNAL 96 (3),1210-1217頁
2008/07	論文	ATP hydrolysis and synthesis of a rotary motor V-ATPase from Thermus thermophilus JOURNAL OF BIOLOGICAL CHEMISTRY 283 (30),20789-20796頁
2008/07	論文	Molecular mechanism of energy conservation in polysulfide respiration Nature Structural and Molecular Biology 15 (7),730-737頁
2007/12	論文	Dodecamer rotor ring defines H+/ATP ratio for ATP synthesis of prokaryotic V-ATPase from Thermus thermophilus PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 104 (51),20256-20261頁
2007/05	その他	[Two rotary molecular motors, V-ATPase and F0F1]. Seikagaku. The Journal of Japanese Biochemical Society 79 (5),425-437頁
2007/04	その他	[Unveiled multifunctionality of V-ATPase and the molecular mechanism revealed by X-ray crystal structures]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 52 (4),335-341頁
2007	その他	非侵襲.可視化技術ハンドブックーナノ・バイオ医療から情報システムまでー
2006/12	論文	Reconstitution in vitro of V-1 complex of Thermus thermophilus V-ATPase revealed that ATP binding to the A subunit is crucial for V-1 formation JOURNAL OF BIOLOGICAL CHEMISTRY 281 (50),38582-38591頁
2006/02	論文	Two-dimensional crystallization and analysis of projection images of intact Thermus thermophilus V-ATPase JOURNAL OF STRUCTURAL BIOLOGY 153 (2),200-206頁
2006/01	論文	Leu(309) plays a critical role in the encapsulation of substrate protein into the internal cavity of GroEL JOURNAL OF BIOLOGICAL CHEMISTRY 281 (2),962-967頁
2005/12	論文	Rotation scheme of V-1-motor is different from that of F-1-motor PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102 (50),17929-17933頁
2005/12	論文	Rotation, structure, and classification of prokaryotic V-ATPase JOURNAL OF BIOENERGETICS AND BIOMEMBRANES 37 (6),405-410頁
2005/11	論文	Structure of a central stalk subunit F of prokaryotic V-type ATPase/synthase from Thermus thermophilus EMBO JOURNAL 24 (22),3974-3983頁
2004/09	その他	[The sophisticated proton pump, V-type ATPase]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 49 (12),2035-2043頁
2004/08	その他	Crystal structure of the native chaperonin complex from Thermus thermophilus revealed unexpected asymmetry at the cis-cavity. Structure (London, England : 1993) 12 (8),1471-1480頁
2004/04	論文	The F subunit of Thermus thermophilus V-1-ATPase promotes ATPase activity but is not necessary for rotation JOURNAL OF BIOLOGICAL CHEMISTRY 279 (17),18085-18090頁
2004/01	論文	Crystal structure of a central stalk subunit C and reversible association/dissociation of vacuole-type ATPase PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101 (1),59-64頁
2003/10	論文	Subunit arrangement in V-ATPase from Thermus thermophilus JOURNAL OF BIOLOGICAL CHEMISTRY 278 (43),42686-42691頁
2003/09	論文	Crystallization of the chaperonin GroEL-GroES complex from Thermus thermophilus HB8 ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 59 (Pt 9),1632-1634頁
2003/07	論文	Rotation of the proteolipid ring in the V-ATPase JOURNAL OF BIOLOGICAL CHEMISTRY 278 (27),24255-24258頁
2003/06/01	論文	Different roles of proteolipids and 70-kDa subunits of V-ATPase in growth and death of cultured human cells Genes to Cells 8 (6),501-513頁
2003/03	論文	Evidence for rotation of V-1-ATPase PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100 (5),2312-2315頁
2002/04	論文	Extended longevity of Caenorhabditis elegans by knocking in extra copies of hsp70F, a homolog of mot-2 (mortalin)/mthsp70/Grp75 FEBS LETTERS 516 (1-3),53-57頁
2000/05/05	論文	V-type H+-ATPase/synthase from a thermophilic eubacterium, Thermus thermophilus. Subunit structure and operon Journal of Biological Chemistry 275 (18),13955-13961頁
2000	その他	V-type H⁺ATPase/synthase from a thermophilic eubacterium, Thermus thermophilus THE JOURNAL OF BIOLOGICAL CHEMISTRY 275/18,13955-13961
2000	その他	V-type H⁺ATPase/synthase from a thermophilic eubacterium, Thermus thermophilus
1999/05	論文	-Activated lansoprazole inhibits cancer cell adhesion to extracellular matrix components. S. Intern. J. Oncol. 359,53-55頁
1999/05	その他	18. Gene cloning and overexpression of a geranylgeranyl diphosphate synthase of an extremely thermophilic bacterium, Thermus thermophilus. Biosci.Biothechnol.Biochem. 359,53-55頁
1999	その他	Gene cloning and overexpression of a geranylgeranyl diphosphate synthase of an extremely thermophilic bacterium, Thermus thermophilus Biosci. Biotechnol. Biochem. 63/,261-270
1999	その他	Gene cloning and overexpression of a geranylgeranyl diphosphate synthase of an extremely thermophilic bacterium, Thermus thermophilus
1998/11	論文	V-ATPase from Thermus thermophilus is inactivated during ATP hydrolysis but can synthesis ATP. The Journal of Biological Chemistry 273,12248-12252頁
1998/08	論文	-Prodigiosins uncouple mitochondrial and bacterial F-ATPases: evidence for their H+/Cl- symport activity. J. Biochem. 124,547-556頁
1998	その他	V-ATPase of Thermusthermophilus in Inactivated during ATP hydrolysis but can synthesis ATP The Journal of Biological Chemistry 237/32,20504
1998	その他	V-ATPase of Thermusthermophilus in Inactivated during ATP hydrolysis but can synthesis ATP
1994/10	論文	Isolation of prokaryotic VoV1-ATPase from a thermophilic eubacterium Thermus thermophilus. The Journal of Biological Chemistry 269,12248-12253頁
1994	その他	Isolation of prokaryotic V₀V₁-ATPase from a thermophilic eubacterium Thermus thermophilus J. Biol. Chem. 269/,12248
1994	その他	Isolation of prokaryotic V₀V₁-ATPase from a thermophilic eubacterium Thermus thermophilus
1993/06	論文	The TF1-ATPase and ATPase activities of assembled  and  complexes are stimulated by low and inhibited by high concentrations of rhodamine 6G whereas the dye only inhibits the , and complexes. J-Bioenerg-Biomembr. 25,679-684頁
1993	その他	The TF₁-ATPase and ATPase activities of assembled α₃β₃γ, α₃β₃γδ, α₃β₃γe complexes are stimulated by low and inhibited by high concentrations of rhodamine 6G J. Bioenerg. Biomembr. 25/,679
1993	その他	The TF₁-ATPase and ATPase activities of assembled α₃β₃γ, α₃β₃γδ, α₃β₃γe complexes are stimulated by low and inhibited by high concentrations of rhodamine 6G
1993	その他	Thermostable farnesyl diphosphate synthase of Bacillus stearothermophilus J. Biochem. 113/,355
1993	その他	Thermostable farnesyl diphosphate synthase of Bacillus stearothermophilus
1992/02	論文	Single site hydrolysis of 2',3'-O-(2,4,6-trinitrophenyl)-ATP by the F1-ATPase from thermophilic bacterium PS3 is accelerated by the chase-addition of excess ATP. The Journal of Biological Chemistry 267,4551-4555頁
1992	その他	Single site hydrolysis of 2', 3'-0-(2, 4, 6-trinitrophenyl)-ATP by the F1-ATPase from thermophilic bacterium PS3 is accelerated by the chase-addition of excess ATP J. Biol. Chem. 267/,4551
1992	その他	Single site hydrolysis of 2', 3'-0-(2, 4, 6-trinitrophenyl)-ATP by the F1-ATPase from thermophilic bacterium PS3 is accelerated by the chase-addition of excess ATP
1991	論文	Purification by dye-ligand chromatography and a crystallization study of the F1-ATPase and its major subunits, β and α, from a thermophilic bacterium, PS3 Journal of Biochemistry 109 (3),466-471頁
1991	その他	Molecular cloning of genes encoding major two subunits of a eubacterial V-type ATPase from Thermus thermophilus Biochim Biophys Acta 1098/,13
1991	その他	Molecular cloning of genes encoding major two subunits of a eubacterial V-type ATPase from Thermus thermophilus
1991	その他	Purification by dye-ligand chromatography and a crystallization study of the F₁-ATPase and its major subunits, beta and alpha, from a thermophilic bacterium, PS3 J. Biochem. 109/,466
1991	その他	Purification by dye-ligand chromatography and a crystallization study of the F₁-ATPase and its major subunits, beta and alpha, from a thermophilic bacterium, PS3
1990/10/01	論文	Electron microscopy of the reconstituted complexes of the F1-ATPase with various subunit constitution revealed the location of the γ subunit in the central cavity of the molecule FEBS Letters 271 (1-2),111-115頁
1990	論文	Thermus thermophilus membrane-associated ATPase. Indication of a eubacterial V-type ATPase Journal of Biological Chemistry 265 (35),21946-21950頁
1990	その他	Electron microscopy of the reconstituted complexes of the F1-ATPase with various subunit constituted revealed the location of the gamma subunit in the central cavity of the molecule FEBS Lett. 271/,111
1990	その他	Electron microscopy of the reconstituted complexes of the F1-ATPase with various subunit constituted revealed the location of the gamma subunit in the central cavity of the molecule
1990	その他	Thermus thermophilus membrane-associated ATPase Indication of a eubacterial V-type ATPase
1989	論文	The reconstituted α3 β3 δ complex of the thermostable F1-ATPase J. Biol. Chem. 264/,21837,21837
1989	論文	The reconstituted α3β3δ complex of the thermostable F1-ATPase Journal of Biological Chemistry 264 (36),21837-21841頁
1989	その他	The reconstituted α3 β3 δ complex of the thermostable F1-ATPase