教員情報 - 津下　英明 | 京都産業大学

ツゲ　ヒデアキ TSUGE HIDEAKI
津下　英明

所属

京都産業大学生命科学部先端生命科学科

職種教授

著書・論文歴
2024/07	論文	General ADP-Ribosylation Mechanism Based on the Structure of ADP-Ribosyltransferase-Substrate Complexes. Toxins 16 (7) (共著)
2024/05	論文	Structural Elucidation and Antiviral Activity of Covalent Cathepsin L Inhibitors. Journal of medicinal chemistry 67 (9),7048-7067 (共著)
2022/10	論文	Cryo-EM structures of the translocational binary toxin complex CDTa-bound CDTb-pore from Clostridioides difficile Nature Communications (共著)
2021/01	論文	Common Mechanism for Target Specificity of Protein- and DNA-Targeting ADP-Ribosyltransferases Toxins 13 (1),40-40頁 (共著)
2021	論文	Preparation of Clostridium perfringens binary iota-toxin pore complex for structural analysis using cryo-EM. Methods in enzymology 649,125-148頁
2020/06/26	論文	A myelin sheath protein forming its lattice Journal of Biological Chemistry 295 (26),8706-8707頁
2020/03	論文	Cryo-EM structures reveal translocational unfolding in the clostridial binary iota toxin complex Nature Structural & Molecular Biology 27 (3),288-296頁 (共著)
2018/09/07	論文	Substrate N2 atom recognition mechanism in pierisin family DNA-targeting, guanine-specific ADP-ribosyltransferase ScARP Journal of Biological Chemistry
2018/02	その他	Aeromonas sobriaセリンプロテアーゼの基質認識におけるArg-566の関与(Involvement of the Arg-566 residue of Aeromonas sobria serine protease in substrate specificity) 日本細菌学雑誌 73 (1),108-108頁
2017/10/12	論文	Involvement of the Arg566 residue of Aeromonas sobria serine protease in substrate specificity PLoS One 12 (10)
2017/02/15	論文	Crystal structure and structure-based mutagenesis of actin-specific ADP-ribosylating toxin CPILE-a as novel enterotoxin PLOS ONE 12 (2)
2016/08	論文	Comparative Studies of Actin- and Rho-Specific ADP-Ribosylating Toxins: Insight from Structural Biology. Curr Top Microbiol Immunol.- The actin Cytoskeleton and Bacterial Infection 99,69-86頁
2016/01	論文	Anabaena sp. DyP-type peroxidase is a tetramer consisting of two asymmetric dimers. Proteins 84 (1),31-42頁
2015/12	論文	Conformational plasticity is crucial for C3-RhoA complex formation by ARTT-loop. PATHOGENS AND DISEASE 73 (9)
2015/08/07	論文	Rho GTPase Recognition by C3 Exoenzyme Based on C3-RhoA Complex Structure Journal of Biological Chemistry 290 (32),19423-19432頁
2015/03	論文	Structural Basis for Action of the External Chaperone for a Propeptide-deficient Serine Protease from Aeromonas sobria. The Journal of Biological Chemistry 290 (17),11130-11143頁
2015	論文	Enteric toxins of Clostridium perfringens: Beta-toxin, tpeL, epsilon-toxin and iota-toxin. Molecular Medical Microbiology (Second edition) 2,997-1013頁
2015	論文	Reaction Mechanism of Mono-ADP-Ribosyltransferase Based on Structures of the Complex of Enzyme and Substrate Protein. Curr Top Microbiol Immunol.-ENDOGENOUS ADP-RIBOSYLATION 384 (384),69-87頁
2015	その他	7. ADPリボシル化RhoAの立体構造に基づく阻害機構(第438回研究協議会研究発表要旨,ビタミンB研究委員会) ビタミン 89 (3),153-154頁
2014/09	論文	Substrate selectivity of bacterial monoacylglycerol lipase based on crystal structure. J Struct Funct Genomics. (15(3)),83-9
2014/09	その他	修飾酵素と基質タンパク質の反応前後における複合体結晶の作製と構造に基づく反応機構 : ウェルシュ菌イオタ毒素laによるアクチンの修飾機構放射光 : 日本放射光学会誌 27 (5),233-240頁
2014/01	論文	Crystallization and preliminary X-ray diffraction studies of a surface mutant of the middle domain of PB2 from human influenza A (H1N1) virus. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS 70 (70(Pt 1)),72-75頁
2013/03	論文	Arginine ADP-ribosylation mechanism based on structural snapshots of iota-toxin and actin complex. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110 (18),7524-7524頁
2013	論文	Conformational polymorphism of m7GTP in crystal structure of the PB2 middle domain from human influenza A virus. PLOS ONE 8 (11)
2012/09	論文	[The tertiary structures of the domains of influenza RNA polymerase]. Seikagaku 84 (9),780-785頁
2012	論文	Crystal structures of dye-decolorizing peroxidase with ascorbic acid and 2,6-dimethoxyphenol FEBS Letters 586 (24),4351-4356頁
2012	論文	Role of side-edge site of sphingomyelinase from Bacillus cereus Biochemical and Biophysical Research Communications 422 (1),128-132頁
2012	論文	Role of sphingomyelinase in infectious diseases caused by Bacillus cereus PLoS ONE 7 (6)
2011/12	論文	Structural Basis of Free Reduced Flavin Generation by Flavin Reductase from Thermus thermophilus HB8 JOURNAL OF BIOLOGICAL CHEMISTRY 286 (51),44078-44085頁
2011/11	論文	Structure and stability of Gyuba, a beta-lactoglobulin chimera PROTEIN SCIENCE 20 (11),1867-1875頁
2011/07	論文	The catalytic mechanism of dye-decolorizing peroxidase DyP may require the swinging movement of an aspartic acid residue FEBS JOURNAL 278 (13),2387-2394頁
2010/08	その他	【Helicobacter pyloriの遺伝子を用いた研究病原因子から分子疫学まで】Helicobacter pyloriのTipαによるヌクレオリンを介した発がん促進機構 Helicobacter Research 14 (4),258-264頁
2010/06	論文	Nucleolin as cell surface receptor for tumor necrosis factor-alpha inducing protein: a carcinogenic factor of Helicobacter pylori JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 136 (6),911-921頁
2010	その他	Helicobacter pyloriの遺伝子を用いた研究:病原因子から分子疫学まで Helicobacter pyloriのTipαによるヌクレオリンを介した発がん促進機構 Helicobacter Research 14 (4)
2009/12	論文	The carboxy-terminal tail of Aeromonas sobria serine protease is associated with the chaperone MICROBIOLOGY AND IMMUNOLOGY 53 (12),647-657頁
2009/12	その他	Clostridium perfringens iota-toxin: structure and function. Toxins 1,208-228頁
2009/11/25	その他	Correction to the article "non-native α-helix formation is not necessary for folding of lipocalin: Comparison of burst-phase folding between tear lipocalin and β-lactoglobulin" (Proteins: Structute, Function and Bioformatics (2009) 76, (226-236)) Proteins: Structure, Function and Bioinformatics 77,1015
2009/10	論文	Refolding, characterization and crystal structure of (S)-malate dehydrogenase from the hyperthermophilic archaeon Aeropyrum pernix BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 1794 (10),1496-1504頁
2009/10	論文	Structural basis for the Helicobacter pylori-carcinogenic TNF-alpha-inducing protein BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 388 (2),193-198頁
2009/10	論文	Structural Basis for the Kexin-like Serine Protease from Aeromonas sobria as Sepsis-causing Factor JOURNAL OF BIOLOGICAL CHEMISTRY 284 (40),27655-27663頁
2009/07	論文	Non-native alpha-helix formation is not necessary for folding of lipocalin: Comparison of burst-phase folding between tear lipocalin and beta-lactoglobulin PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 76 (1),226-236頁
2009/03	論文	Structural Basis of the Influenza A Virus RNA Polymerase PB2 RNA-binding Domain Containing the Pathogenicity-determinant Lysine 627 Residue JOURNAL OF BIOLOGICAL CHEMISTRY 284 (11),6855-6860頁
2009/02	論文	Crystallization and X-ray diffraction analysis of the RNA primer/promoter-binding domain of influenza A virus RNA-dependent RNA polymerase PB2 ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS 65 (65:),144-146頁
2009/01	論文	Structural analysis of human glutamine:fructose-6-phosphate amidotransferase, a key regulator in type 2 diabetes FEBS LETTERS 583 (1),163-167頁
2009	その他	1SA3-02 Structural basis of the influenza A virus RNA polymerase PB2 RNA-binding domain containing the pathogenicitydeterminant lysine 627 residue(1SA3 Novel findings of influenza A virus RNA dependent RNA polymerase,The 47th Annual Meeting of the Biophysical Society of Japan) Seibutsu Butsuri 49,S5
2009	その他	3P-004 Crystal structure of influenza virus RNA polymerase PB2 including host determinant residue K627(Protein:Structure,The 47th Annual Meeting of the Biophysical Society of Japan) Seibutsu Butsuri 49,S151
2009	その他	超好熱性アーキアのフラビン含有アミノ酸脱水素酵素の機能と構造、及び応用日本応用酵素協会誌 43,33-44頁
2008/06	論文	Structure of an archaeal alanine : glyoxylate aminotransferase ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 64 (64(6):),696-699頁
2008/05	論文	Structural basis of actin recognition and arginine ADP-ribosylation by Clostridium perfringens L-toxin PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 105 (21),7399-7404頁
2008/03	論文	Crystal structure of the YdjC-family protein TTHB029 from Thermus thermophilus HB8: Structural relationship with peptidoglycan N-acetylglucosamine deacetylase BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 367 (3),535-541頁
2008/03	論文	Structure of L-aspartate oxidase from the hyperthermophilic archaeon Sulfolobus tokodaii BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 1784 (3),563-571頁
2007/11	論文	Sequential aldol condensation catalyzed by hyperthermophilic 2-deoxy-D-ribose-5-phosphate aldolase APPLIED AND ENVIRONMENTAL MICROBIOLOGY 73 (22),7427-7434頁
2007/08	論文	Crystal structure of archaeal highly thermostable L-aspartate dehydrogenase/NAD/citrate ternary complex FEBS JOURNAL 274 (16),4315-4325頁
2007/04	論文	Structural basis of D-DOPA oxidation by D-amino acid oxidase: Alternative pathway for dopamine biosynthesis BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 355 (2),385-391頁
2007/01	論文	Structure of a hyperthermophilic archaeal homing endonuclease, I-Tsp061I: Contribution of cross-domain polar networks to thermostability JOURNAL OF MOLECULAR BIOLOGY 365 (2),362-378頁
2007	論文	Human D-amino acid oxidase: an update and review CHEMICAL RECORD 7 (5),305-315頁
2007	その他	1P030 Molecular Mechanism of Actin Recognition by Arginine ADP-ribosylating Toxin(Proteins-functions, methodology, and protein enigineering,Oral Presentations) Seibutsu Butsuri 47,S31
2006/12	論文	Crystal structure of human D-amino acid oxidase: Context-dependent variability of the backbone conformation of the VAAGL hydrophobic stretch located at the si-face of the flavin ring PROTEIN SCIENCE 15 (12),2708-2717頁
2006/06	論文	Structural basis of the sphingomyelin phosphodiesterase activity in neutral sphingomyelinase from Bacillus cereus JOURNAL OF BIOLOGICAL CHEMISTRY 281 (23),16157-16167頁
2006/01/01	その他	Novel diflavin-containing dehydrogenase family: FAD, FMN and ATP-containing L-proline dehydrogenase Seikagaku. The Journal of Japanese Biochemical Society. 78,41-45頁
2006	その他	超好熱菌タンパク質の耐熱化の分子戦略化学と生物 44 (5),305-312頁
2005/09	論文	Crystal structure of a novel FAD-, FMN-, and ATP-containing L-proline dehydrogenase complex from Pyrococcus horikoshii JOURNAL OF BIOLOGICAL CHEMISTRY 280 (35),31045-31049頁
2005/08	論文	A second novel dye-linked L-proline dehydrogenase complex is present in the hyperthermophilic archaeon Pyrococcus horikoshii OT-3 FEBS JOURNAL 272 (16),4044-4054頁
2005/07	その他	Crystal structure of the NAD biosynthetic enzyme quinolinate synthase JOURNAL OF BIOLOGICAL CHEMISTRY 280 (29),26645-26648頁
2005/03/25	その他	超好熱菌由来アルドラーゼのユニークな4次構造と高度耐熱性生物物理 45 (2),97-100頁
2005/01	論文	The first crystal structure of hyperthermostable NAD-dependent glutamate dehydrogenase from Pyrobaculum islandicum JOURNAL OF MOLECULAR BIOLOGY 345 (2),325-337頁
2005	その他	1P019 Aeromonas sobria由来セリンプロテアーゼのX線結晶構造解析(蛋白質 A) 構造)) 生物物理 45,S36
2005	その他	1P045 超好熱アーキアP. aerophilum由来2-Deoxyribose-5-PhosphateAldolaseのX線結晶構造解析(蛋白質 B) 構造・機能相関)) 生物物理 45,S43
2005	その他	1P107 (Pro)caspase-3のアクティベーター及び阻害剤との複合体の探索(蛋白質 D) 機能(反応機構、生物活性など))) 生物物理 45,S58
2005	その他	1SE53 相互作用解析のための複合体サンプルの調整(インタラクトーム構造生物学の展開に向けて) 生物物理 45,S16
2005	その他	2P014 Thermus thermophilus HB8由来タンパク質TTHA0420のX線結晶構造解析(蛋白質 A) 構造)) 生物物理 45,S123
2005	その他	2P048 NAD生合成系酵素キノリン酸シンターゼの結晶構造(蛋白質 B) 構造・機能相関)) 生物物理 45,S131
2005	その他	5.超好熱アーキアPyrococcus horikoshiiの新規プロリン脱水素酵素 : 補欠分子族の同定と立体構造解析(ビタミンB研究委員会第399回研究協議会研究発表要旨) ビタミン 79 (3),184-185頁
2005	その他	The first crystal structure of an archaeal helical repeat protein. Acta Cryst. F (61(7)),636-639.
2004/11	論文	Crystallization and preliminary X-ray diffraction analysis of homing endonuclease I-Tsp061I ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 60 (60(11)),2006-2008頁
2004/04/25	その他	2-III-15 超好熱アーキアPyrococcus horikoshii OT-3から発見されたフラビン酵素,色素依存性L-プロリン脱水素酵素の機能と構造(第56回大会一般研究発表) ビタミン 78 (4),253-253頁
2004/04	論文	Crystallization and preliminary X-ray diffraction analysis of the hyperthermostable NAD-dependent glutamate dehydrogenase from Pyrobaculum islandicum ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 60 (60(4)),715-717頁
2004	論文	Amino-acid residues involved in the expression of the activity of Escherichia coli ToIC MICROBIOLOGY AND IMMUNOLOGY 48 (10),713-722頁
2004	その他	2P010 P. horikoshii由来L-プロリン脱水素酵素のX線結晶構造解析(蛋白質 A) 構造) 生物物理 44,S112
2004	その他	2P013 H.pyloriから分泌される新規分泌TNF-α誘導タンパク質(Tip)のX線結晶構造解析(蛋白質 A) 構造) 生物物理 44,S113
2004	その他	3P050 大腸菌で生産されるPyrobaculum islandicum由来のグルタミン酸脱水素酵素の活性化機構(蛋白質 C) 物性 : 安定性、折れたたみなど) 生物物理 44,S202
2003/03	論文	The first crystal structure of archaeal aldolase - Unique tetrameric structure of 2-deoxy-D-ribose-5-phosphate aldolase from the hyperthermophilic archaea Aeropyrum pernix JOURNAL OF BIOLOGICAL CHEMISTRY 278 (12),10799-10806頁
2003/01	論文	Crystal structure and site-directed mutagenesis of enzymatic components from Clostridium perfringens iota-toxin JOURNAL OF MOLECULAR BIOLOGY 325 (3),471-483頁
2003	論文	Clostridium perfringens iota-toxin, ADP-ribosyltransferase: structure and mechanism of action ADVANCES IN ENZYME REGULATION, VOL 43 43,361-377頁
2003	その他	1A16-2 Crystallization and preliminary X-ray diffraction analysis of L-aspartate oxidase from the hyperthermophilic archaeon, Pyrococcus furiosus : 日本生物工学会大会講演要旨集 15,48-48頁
2002/12	論文	Chondroitin sulfate proteoglycan is a potent enhancer in the processing of procathepsin L BIOLOGICAL CHEMISTRY 383 (12),1925-1929頁
2002/10	論文	Crystal structure of the ADP-dependent glucokinase from Pyrococcus horikoshii at 2.0-angstrom resolution: A large conformational change in ADP-dependent glucokinase PROTEIN SCIENCE 11 (10),2456-2463頁
2002/08	論文	Crystallization and preliminary X-ray diffraction analysis of glutamate dehydrogenase from an aerobic hyperthermophilic archaeon, Aeropyrum pernix K1 ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 58,1338-1339頁
2002/07	論文	Crystallization and preliminary X-ray crystallographic studies of monoacylglycerol lipase of the moderately thermophilic Bacillus sp H-257 ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 58,1232-1233頁
2002/01	論文	Structure-based design of specific cathepsin inhibitors and their application to protection of bone metastases of cancer cells ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 397 (2),305-311頁
2002	論文	Structure-based development of cathepsin L inhibitors and therapeutic applications for prevention of cancer metastasis and cancer-induced osteoporosis ADVANCES IN ENZYME REGULATION, VOL 42, PROCEEDINGS 42,159-172頁
2002	その他	3H1015 超好熱菌由来2-デオキシリボース-5-リン酸アルドラーゼのX線結晶構造解析(1.蛋白質(A)構造,一般講演,日本生物物理学会第40回年会) 生物物理 42 (2),S168
2001/04/25	その他	2-III-14 超好熱アーキアPyrococcus horikoshii OT-3のNAD生合成系の解明 : L-アスパラギン酸オキシダーゼの機能と構造ビタミン 75 (4),243-243頁
2001	その他	1P015超好熱古細菌P.furiosusのADP依存性グルコキナーゼの結晶構造生物物理 41,S36
2000	その他	2C1545 Clostridium Perfringens Ia-アクチン特異的ADPリボシルトランスフェラーゼの結晶構造生物物理 40,S121
2000	その他	カテプシンL選別的阻害剤のStructure Based Drug Design 法による開発生物工学 78巻10号 421-424/,
1999/12	論文	Inhibition mechanism of cathepsin L-specific inhibitors based on the crystal structure of papain-CLIK148 complex BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 266 (2),411-416頁
1999/09	論文	Structure based development of novel specific inhibitors for cathepsin L and cathepsin S in vitro and in vivo FEBS LETTERS 458 (1),6-10頁
1999/08	その他	ヒト特異的細胞溶解毒素インターメディリシンとコレステロール結合性毒素の立体構造の比較生化学 71 (8),1016-1016頁
1999/06	論文	Crystallization and preliminary X-ray studies of the Ia component of Clostridium perfringens iota toxin complexed with NADPH JOURNAL OF STRUCTURAL BIOLOGY 126 (2),175-177頁
1996/09	論文	Structure of the human cytomegalovirus protease catalytic domain reveals a novel serine protease fold and catalytic triad CELL 86 (5),835-843頁
1994/10	論文	X-RAY STRUCTURE OF A POKEWEED ANTIVIRAL PROTEIN, CODED BY A NEW GENOMIC CLONE, AT 0.23 NM RESOLUTION - A MODEL STRUCTURE PROVIDES A SUITABLE ELECTROSTATIC-FIELD FOR SUBSTRATE-BINDING EUROPEAN JOURNAL OF BIOCHEMISTRY 225 (1),369-374頁
1994	その他	Crystallization and preliminary-x-ray crystallographic studies of recombinant human Leukotriene A4 hydrolase complexed with bestatin. Journal of Molecular Biology 238 (5),854-856頁
1993/04	論文	NUCLEOTIDE-SEQUENCE OF A GENOMIC GENE ENCODING TRITIN, A RIBOSOME-INACTIVATING PROTEIN FROM TRITICUM-AESTIVUM PLANT MOLECULAR BIOLOGY 22 (1),171-176頁
1992/07	論文	CRYSTALLIZATION AND PRELIMINARY-X-RAY CRYSTALLOGRAPHIC ANALYSIS OF MIRABILIS ANTIVIRAL PROTEIN JOURNAL OF MOLECULAR BIOLOGY 226 (1),281-283頁
1992/02	論文	CRYSTALLOGRAPHIC STUDIES OF A CALCIUM-BINDING LYSOZYME FROM EQUINE MILK AT 2.5 A RESOLUTION JOURNAL OF BIOCHEMISTRY 111 (2),141-143頁