教員情報 - 板野　直樹 | 京都産業大学

イタノ　ナオキ ITANO NAOKI
板野　直樹

所属

京都産業大学生命科学部先端生命科学科

職種教授

著書・論文歴
2024/01	論文	Tolerable glycometabolic stress boosts cancer cell resilience through altered N-glycosylation and Notch signaling activation. Cell death & disease 15 (1),53 (共著)
2023/08	論文	Trophoblast cell surface antigen-2 phosphorylation triggered by binding of galectin-3 drives metastasis through down-regulation of E-cadherin. The Journal of biological chemistry 299 (8),104971 (共著)
2023/01	論文	Dysregulation of hexosamine biosynthetic pathway wiring metabolic signaling circuits in cancer. Biochimica et biophysica acta. General subjects 1867 (1),130250 (共著)
2021/10	論文	The membrane-linked adaptor FRS2β fashions a cytokine-rich inflammatory microenvironment that promotes breast cancer carcinogenesis. Proceedings of the National Academy of Sciences of the United States of America 118 (43) (共著)
2020	論文	Hyaluronan: Metabolism and Function. Biomolecules 10,1525
2019	論文	Enhanced hexosamine metabolism drives metabolic and signaling networks involving hyaluronan production and O-GlcNAcylation to exacerbate breast cancer. Cell Death & Disease 10,803
2018	論文	Metabolic Reprogramming and Hyaluronan Production in Cancer Stem Cells. Trends in Glycosci. Glycotechnol. 30 (176),E147-E154頁
2016/11	論文	Hyaluronan Production Regulates Metabolic and Cancer Stem-like Properties of Breast Cancer Cells via Hexosamine Biosynthetic Pathway-coupled HIF-1 Signaling JOURNAL OF BIOLOGICAL CHEMISTRY 291 (46),24105-24120頁
2016/05	その他	Hyaluronan: A modulator of the tumor microenvironment CANCER LETTERS 375 (1),20-30頁
2015	著書	Hyaluronan: cancer and cancer metastasis,1411-1417頁 (共著)
2015	その他	Key roles of hyaluronan and its CD44 receptor in the stemness and survival of cancer stem cells Frontiers in Oncology 5 (180)
2014/09	論文	Excessive Hyaluronan Production Promotes Acquisition of Cancer Stem Cell Signatures through the Coordinated Regulation of Twist and the Transforming Growth Factor beta (TGF-beta)-Snail Signaling Axis JOURNAL OF BIOLOGICAL CHEMISTRY 289 (38),26038-26056頁
2014/09	その他	Tumor-Associated Macrophages as Major Players in the Tumor Microenvironment CANCERS 6 (3),1670-1690頁
2014/06	論文	New Visible Endotracheal Intubation Method Using the Endoscope System for Mice Inhalational Anesthesia JOURNAL OF VETERINARY MEDICAL SCIENCE 76 (6),863-868頁
2014/04	論文	Hyaluronan Deficiency Due to Has3 Knock-Out Causes Altered Neuronal Activity and Seizures via Reduction in Brain Extracellular Space JOURNAL OF NEUROSCIENCE 34 (18),6164-6176頁
2014/01	論文	Effect of a cholesterol-rich lipid environment on the enzymatic activity of reconstituted hyaluronan synthase BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 443 (2),666-671頁
2014	著書	Biosynthetic pathways of proteoglycans,1681-1686頁 (共著)
2014	著書	Hyaluronan synthase 1-3 (HAS1-3),865-872頁 (共著)
2013/07	論文	ASC-associated inflammation promotes cecal tumorigenesis in aryl hydrocarbon receptor-deficient mice CARCINOGENESIS 34 (7),1620-1627頁
2013/03/06	論文	Crucial Role of Hyaluronan in Neointimal Formation after Vascular Injury PLoS ONE 8 (3),e58760
2013	論文	－糖鎖と疾患‐ 癌進展におけるヒアルロン酸腫瘍微小環境の役割病理と臨床 31,875-882頁
2012/07	論文	Hyaluronan Expressed by the Hematopoietic Microenvironment Is Required for Bone Marrow Hematopoiesis JOURNAL OF BIOLOGICAL CHEMISTRY 287 (30),25419-25433頁
2012/03	論文	Restriction of Mast Cell Proliferation through Hyaluronan Synthesis by Co-cultured Fibroblasts BIOLOGICAL & PHARMACEUTICAL BULLETIN 35 (3),408-412頁
2012/01	論文	Enhanced Inflammation and Accelerated Wound Closure Following Tetraphorbol Ester Application or Full-Thickness Wounding in Mice Lacking Hyaluronan Synthases Has1 and Has3 JOURNAL OF INVESTIGATIVE DERMATOLOGY 132 (1),198-207頁
2011/09	その他	Inflammatory alterations of the extracellular matrix in the tumor microenvironment Cancers 3 (3),3189-3205頁
2011	論文	ASC plays a role in the priming phase of the immune response to type II collagen in collagen-induced arthritis. Rheumatol Int. 10
2011	論文	Clinicopathological Role of Serum-Derived Hyaluronan-Associated Protein (SHAP)-Hyaluronan Complex in Endometrial Cancer. Obstet. Gynecol. Int. 2011,739150
2010/09	論文	Exercise Effects on Methylation of ASC Gene INTERNATIONAL JOURNAL OF SPORTS MEDICINE 31 (9),671-675頁
2010/09	論文	Hyaluronan Deficiency in Tumor Stroma Impairs Macrophage Trafficking and Tumor Neovascularization CANCER RESEARCH 70 (18),7073-7083頁
2010/04	論文	Calponin h1-S175T Point Mutation Enhances Resistance to Actin Cytoskeleton Perturbation in Human Cancer Cells ANTICANCER RESEARCH 30 (4),1071-1078頁
2010	論文	Role of hyaluronan synthase, hyaluronan and serum-derived hyaluronan-associated protein (SHAP)-hyaluronan complex in endometrial cancer. J. Aichi Med. Univ. Assoc. 38,29-42頁
2009/10	論文	Mycobacteria Exploit Host Hyaluronan for Efficient Extracellular Replication PLOS PATHOGENS 5 (10),e1000643
2009/04	論文	Involvement of CD44 in mast cell proliferation during terminal differentiation LABORATORY INVESTIGATION 89 (4),446-455頁
2009/04	論文	Role of ASC in the Mouse Model of Helicobacter pylori Infection JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 57 (4),327-338頁
2009	論文	A Splice Variant of ASC Regulates IL-1 beta Release and Aggregates Differently from Intact ASC MEDIATORS OF INFLAMMATION 2009,287387
2008/09	その他	Impact of the hyaluronan-rich tumor microenvironment on cancer initiation and progression CANCER SCIENCE 99 (9),1720-1725頁
2008/08	その他	Altered hyaluronan biosynthesis in cancer progression SEMINARS IN CANCER BIOLOGY 18 (4),268-274頁
2008/08	その他	Simple primary structure, complex turnover regulation and multiple roles of hyaluronan JOURNAL OF BIOCHEMISTRY 144 (2),131-137頁
2008/05	論文	Reduction of Calponin h1 expression in human colon cancer blood vessels EJSO 34 (5),531-537頁
2008/03	論文	Up-regulation of hyaluronan synthase genes in cultured human epidermal keratinocytes by UVB irradiation ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 471 (1),85-93頁
2008/01	論文	Significance of tumor-associated stroma in promotion of intratumoral lymphangiogenesis - Pivotal role of a hyaluronan-rich tumor microenvironment AMERICAN JOURNAL OF PATHOLOGY 172 (1),179-193頁
2008	著書	Conditional transgenic mouse of hyaluronan synthase: a potential model of advanced beast cancer.,252-254頁 (単著)
2008	著書	Hyaluronan synthase assay.,70-71頁 (単著)
2008	論文	進行癌モニタリングのおけるヒアルロン酸リッチ腫瘍内微小環境の重要性臨床糖鎖バイオマーカーの開発−糖鎖機能の解明とその応用遺伝子医学MOOK,234-239頁
2007/07	論文	Versican, a major hyaluronan-binding component in the dermis, loses its hyaluronan-binding ability in solar elastosis JOURNAL OF INVESTIGATIVE DERMATOLOGY 127 (7),1657-1663頁
2007/03	論文	Hyperproduction of hyaluronan in Neu-induced mammary tumor accelerates angiogenesis through stromal cell recruitment - Possible involvement of versican/PG-M AMERICAN JOURNAL OF PATHOLOGY 170 (3),1086-1099頁
2007/02	論文	Potential role of high molecular weight hyaluronan in the anti-Candida activity of human oral epithelial cells MEDICAL MYCOLOGY 45 (1),73-79頁
2007	論文	ヒアルロン酸リッチマトリックスによる腫瘍微小環境の形成と血管新生 Functional Glycomics 9,47-53頁
2006/07	論文	SHAP potentiates the CD44-mediated leukocyte adhesion to the hyaluronan substratum JOURNAL OF BIOLOGICAL CHEMISTRY 281 (29),20303-20314頁
2005/06	論文	Role of hyaluronan and hyaluronan synthase in endometrial cancer ONCOLOGY REPORTS 13 (6),1101-1105頁
2005/03	論文	Hyaluronan synthase expression in pleural malignant mesotheliomas VIRCHOWS ARCHIV 446 (3),246-250頁
2005	著書	A mechanism for 4-methylumbelliferone-mediated inhibition of hyaluronan biosynthesis.,147-153頁 (共著)
2005	著書	ヒアルロン酸合成酵素,176-177頁 (共著)
2005	著書	プロテオグリカン分子群の合成と構造異常がもたらす細胞機能の変化—癌浸潤・転移の理解と克服に向けた解析—,299-302頁 (単著)
2005	論文	Transcriptional regulation of hyaluronan synthases by bone morphogenetic protein-2 in mouse mammary chondrocytes. J. Aichi Med. Univ. Assoc. 33,1-6頁
2004/11	論文	A novel inhibition mechanism of hyaluronan synthesis by 4-methylumbelliferone GLYCOBIOLOGY 14 (11),1175-1176頁
2004/10	論文	Hyaluronan synthase expression in ovarian cancer ONCOLOGY REPORTS 12 (4),739-743頁
2004/08	論文	A novel mechanism for the inhibition of hyaluronan biosynthesis by 4-methylumbelliferone JOURNAL OF BIOLOGICAL CHEMISTRY 279 (32),33281-33289頁
2004/07/14	論文	Biological Function of SHAP-Hyaluronan Covalent Complex Chemistry and Biology of Hyaluronan,205-222頁
2004/05	その他	Abnormal hyaluronan synthesis and cancer progression TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY 16 (89),199-210頁
2004/04	論文	In vivo hyaluronan synthesis upon expression of the mammalian hyaluronan synthase gene in Drosophila JOURNAL OF BIOLOGICAL CHEMISTRY 279 (18),18920-18925頁
2004/04	論文	Selective expression and functional characteristics of three mammalian hyaluronan synthases in oncogenic malignant transformation JOURNAL OF BIOLOGICAL CHEMISTRY 279 (18),18679-18687頁
2004/03	論文	Differential regulation by IL-1 beta and EGF of expression of three different hyaluronan synthases in oral mucosal epithelial cells and fibroblasts and dermal fibroblasts: Quantitative analysis using real-time RT-PCR JOURNAL OF INVESTIGATIVE DERMATOLOGY 122 (3),631-639頁
2004	著書	Biological function of hyaluronan-SHAP covalent complex (共著)
2004	論文	Elevated transcript level of hyaluronan synthase1 gene correlates with poor prognosis of human colon cancer CLINICAL & EXPERIMENTAL METASTASIS 21 (1),57-63頁
2004	論文	Expression analysis of three isoforms of hyaluronan synthase and hyaluronidase in the synovium of knees in osteoarthritis and rheumatoid arthritis by quantitative real-time reverse transcriptase polymerase chain reaction ARTHRITIS RESEARCH & THERAPY 6 (6),R514-R520頁
2004	論文	細胞外マトリックスにおけるヒアルロン産の存在様式と癌細胞の運動性 Biotherapy 18,413-420頁
2003/11	論文	CD44 variant exon 6 expressions in colon cancer assessed by quantitative analysis using real time reverse transcriptase-polymerase chain reaction ONCOLOGY REPORTS 10 (6),1919-1924頁
2003/04	論文	Cell spreading controls endoplasmic and nuclear calcium: A physical gene regulation pathway from the cell surface to the nucleus PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100 (9),5181-5186頁
2003	論文	ヒアルロン酸リッチマトリックスと線維化現代医療 5,51-56頁
2003	論文	ヒアルロン酸合成酵素蛋白質核酸酵素（増刊糖鎖機能：第３の生命鎖） 48,1027-1032頁
2003	論文	癌転移とヒアルロン酸 Cytometry Research. 12,121-129頁
2003	論文	転移と細胞外マトリックス日本臨床（増刊号：癌転移—基礎と臨床アップデート） 61,111-115頁
2002/10	その他	Mammalian hyaluronan synthases IUBMB LIFE 54 (4),195-199頁
2002/04	論文	The role of syndecan-2 in regulation of actin-cytoskeletal organization of Lewis lung carcinoma-derived metastatic clones BIOCHEMICAL JOURNAL 363,201-209頁
2002/03	論文	Abnormal accumulation of hyaluronan matrix diminishes contact inhibition of cell growth and promotes cell migration PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99 (6),3609-3614頁
2001	著書	Regulation of hyaluronan synthase : negative effects on the hyaluronan synthetic activity of the mutated HAS protein that has no enzymatic activity.,183-187頁 (共著)
2001	論文	Hyaluronan biosynthesis: A multifaceted process. Connective Tissue 33,221-226頁
2000/01	論文	In vitro synthesis of hyaluronan by a single protein derived from mouse HAS1 gene and characterization of amino acid residues essential for the activity JOURNAL OF BIOLOGICAL CHEMISTRY 275 (1),497-506頁
1999/12	論文	Increased synthesis of hyaluronate enhances motility of human melanoma cells JOURNAL OF INVESTIGATIVE DERMATOLOGY 113 (6),935-939頁
1999/11	論文	Metabolic activities of partially degenerated hypertrophic chondrocytes: gene expression of hyaluronan synthases CELL AND TISSUE RESEARCH 298 (2),317-325頁
1999/09	論文	Receptor for hyaluronan-mediated motility and CD44 expressions in colon cancer assessed by quantitative analysis using real-time reverse transcriptase-polymerase chain reaction JAPANESE JOURNAL OF CANCER RESEARCH 90 (9),987-992頁
1999/08	論文	Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties JOURNAL OF BIOLOGICAL CHEMISTRY 274 (35),25085-25092頁
1999/05	論文	Relationship between hyaluronan production and metastatic potential of mouse mammary carcinoma cells CANCER RESEARCH 59 (10),2499-2504頁
1999	論文	ヒアルロン酸／ヒアルロン酸合成酵素と細胞接着組織培養工学 25,219-223頁
1999	論文	癌転移研究の手法癌転移と細胞外マトリックス癌と化学療法 26,1663-1668頁
1998/03	論文	The gene structure and promoter sequence of mouse hyaluronan synthase 1 (mHAS1) BIOCHEMICAL JOURNAL 330,1223-1227頁
1998/01	その他	Hyaluronan synthase: New directions for hyaluronan research TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY 10 (51),23-38頁
1998	著書	プロテオグリカン 1. プロテオグリカンの構造と機能,102-112頁 (共著)
1998	論文	ヒアルロン酸合成酵素遺伝子改変によるヒアルロン酸機能解析蛋白質核酸酵素（増刊糖鎖生物学） 43,2387-2393頁
1998	論文	ヒアルロン酸合成酵素：細胞外マトリックス改変に向けてのシナリオ生化学 70,1171-1175頁
1998	論文	プロテオグリカン２癌転移におけるヒアルロン酸の役割週刊医学のあゆみ 184,251-253頁
1997/10	論文	Identification of hyaluronan-binding domains of aggrecan JOURNAL OF BIOLOGICAL CHEMISTRY 272 (44),28057-28065頁
1997/05	論文	Chromosomal localization of the human and mouse hyaluronan synthase genes GENOMICS 41 (3),493-497頁
1997/01	論文	Hyaluronic acid of wound fluid in adult and fetal rabbits JOURNAL OF PEDIATRIC SURGERY 32 (1),41-43頁
1997	論文	Altered expression hyaluronan-rich matrices composed of PG-M/versican, SHAP and hyaluronan in solar elastosis. Nagoya Med. J. 41,27-37頁
1997	論文	転移における細胞外マトリックスの役割 BIO Clinica 12,601-606頁
1996/05	論文	Molecular cloning of human hyaluronan synthase BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 222 (3),816-820頁
1996/05	論文	Phosphorylation of a membrane-intercalated proteoglycan, syndecan-2, expressed in a stroma-inducing clone from a mouse Lewis lung carcinoma BIOCHEMICAL JOURNAL 315,925-930頁
1996/04	論文	Expression cloning and molecular characterization of HAS protein, a eukaryotic hyaluronan synthase JOURNAL OF BIOLOGICAL CHEMISTRY 271 (17),9875-9878頁
1996	論文	プロテオグリカンと癌転移現代医療 28,35-39頁
1995	論文	Glycosaminoglycans in dialysis-related amyloidosis DIALYSIS-RELATED AMYLOIDOSIS 112,83-89頁
1993/12	論文	MEMBRANE-INTERCALATED PROTEOGLYCAN OF A STROMA-INDUCING CLONE FROM LEWIS LUNG-CARCINOMA BINDS TO FIBRONECTIN VIA ITS HEPARAN-SULFATE CHAINS JOURNAL OF BIOCHEMISTRY 114 (6),862-873頁
1992/11	論文	STRUCTURAL DIFFERENCES BETWEEN HEPARAN SULFATES OF PROTEOGLYCAN INVOLVED IN THE FORMATION OF BASEMENT-MEMBRANES INVIVO BY LEWIS-LUNG-CARCINOMA-DERIVED CLONED CELLS WITH DIFFERENT METASTATIC POTENTIALS BIOCHEMICAL JOURNAL 288,215-224頁
1992	論文	ヘパリン様多糖の構造的多様性と生物活性生化学 64,513-520頁
1991	論文	F-ACTIN BUNDLING PROTEIN FROM PHYSARUM-POLYCEPHALUM - PURIFICATION AND ITS CAPACITY FOR CO-BUNDLING OF ACTIN-FILAMENTS AND MICROTUBULES CELL MOTILITY AND THE CYTOSKELETON 19 (4),244-254頁